TLR3 and nasopharyngeal carcinoma: In a previous publication, we have reported that malignant NPC cells are highly sensitive to a treatment combining a TLR3 artificial ligand (poly(I:C)) and a Smac-mimetic, RMT5265 which inhibits several proteins of the IAP family (Inhibition of Apoptosis Proteins; namely c-IAP1, c-IAP2 and XIAP)[18].