The Ph+ ALL is a high-risk acute leukemia with poor prognosis, in which the specific t(9; 22)(q34; q11) translocation results in a chimeric bcr-abl (e1a2 breakpoint) and in a 190 KD protein (p190) with constitutive tyrosine kinase activity. This evidence concerns the gene CNTNAP1 and acute lymphoblastic leukemia.