Hereditary and acquired ABCC2 defects resulting in impaired bilirubin excretion into bile give rise to jaundice (yellow discoloration of skin and sclera/eyes) as one of the most prominent clinical signs of liver.5 Through facilitation of biliary GSH excretion, ABCC2 is one of the critical determinants maintaining (bile acid-independent) bile flow.5 Moreover, many nonconjugated xenobiotics,6 including unmodified anionic drugs,7 are also efficiently transported by ABCC2. Here, ABCC2 is linked to Jaundice.