Probiotic supplementation decreased the incidence of atopic dermatitis (RR 0.79; 95% CI 0.71–0.88) and IgE-mediated atopic dermatitis in infants (RR 0.80; 95% CI 0.66–0.96), when used during pregnancy or early life [117]. The gene discussed is IGHE; the disease is atopic eczema.