To demonstrate the organ-specific role of TR3 in cardiac hypertrophy in vivo, we established another animal model in which endogenous TR3 was specifically knocked down in the left ventricle of the rats but not in other tissues (including the right ventricle, liver, muscle and kidney) by injecting lentivirus-packed siTR3 into the left ventricle (Supporting Information Fig S2A). This evidence concerns the gene NR4A1 and cardiac hypertrophy.