SCRIB and cancer: These data are consistent with previous studies showing that Scrib can act as a tumour suppressor by helping to maintain epithelial organisation and that its expression is downregulated in a number of human cancers (Gardiol et al., 2006; Ivanov et al., 2010b; Navarro et al., 2005; Pearson et al., 2011; Thomas et al., 2005; Zhan et al., 2008).