Scribble acts as a tumour suppressor (Etienne-Manneville, 2009): Drosophila Scrib null mutants exhibit disorganization of epithelial tissues, leading to neoplastic growth and multilayering of epithelial cells (Bilder et al., 2000; Bilder and Perrimon, 2000) and SCRIB expression is decreased in a number of human cancers (Gardiol et al., 2006; Ivanov et al., 2010a; Navarro et al., 2005; Pearson et al., 2011; Thomas et al., 2005). The gene discussed is SCRIB; the disease is neoplasm.