In light of research suggesting that a disregulation of DA and 5-HT contributes to maladaptive behavior in PDDs[43], TJ-54’s unique mechanism of action as a partial D2 agonist, 5-HT1A agonist, and 5-HT2A antagonist[25], may prove important for both its effectiveness and tolerability in PDD-NOS and Asperger’s disorder. This evidence concerns the gene HTR1A and pervasive developmental disorder - not otherwise specified.