CDH1 and neoplasm: Alterations in other proteins involved in the regulation of the cell cycle, such as p21 and c-myc [66], and growth factor receptors, such as HER-2 and EGFR [67–69], and a decrease of adhesion molecules, such as E-cadherin and β-catenin, and oestrogen and progesterone receptors [20, 69, 70], have also been observed in both human and canine tumours.