Finally, the first attempts of donor selection criteria based on KIR genotyping have been proposed: the studies by Cooley et al. demonstrated protection against relapse and survival benefit when donors with certain KIR B genotypes are used for T-cell replete unrelated donor HCT for AML suggesting KIR genotyping to be incorporated into unrelated donor selection algorithm [25, 26]. Here, KIR3DL1 is linked to acute myeloid leukemia.