The last factors described were thrombogenic factors such as von Willebrand factor (vWF) [49] and fibrinogen [52], and novel risk factors like poliautoimmunity (defined as the presence of more than one autoimmune disease in a single patient) [25, 46, 55, 58], and familial autoimmunity [25] (diverse autoimmune diseases cooccurring within families). Here, VWF is linked to autoimmune disease.