TP53 and hepatocellular carcinoma: according to Wu’s research, they found lobaplatin that could repress the proliferation of 5 HCC cell lines by MTT proliferation assay, with IC50 values ranging from 1.45 to 5.22μg/ml.The most sensitive cell line was P53 wild-type SMMC-7721,and the others were p53 null Hep 3B, p53 mutant Huh-7.suggesting in response to lobaplatin, p53 was active in cell signaling cascade.