ESR1 and cancer: WRAP53 is required for control and induction of p53 upon DNA damage to maintain normal levels of p53 in the cell preventing its deprivation which may then lead to a cancer [12] The identification of Wrap53 as a regulator of p53 shows that dysfunction of Wrap53 itself may be a separate cause leading to a cancer [13, 14]Recent reports suggested that common variations in WRAP53 may independently increase risk of estrogen receptor negative breast cancers [15] and correlates with poor prognosis of head and neck cancer [16].