In families with Li-Fraumeni syndrome most commonly observed neoplasms are: soft tissue sarcomas, osteosarcomas, brain tumors, breast cancer, leukemias, and adrenocortical tumors, but not ovarian cancer [1] However, over 200 epidemiologic studies evaluated ovarian cancer risk associated with SNP variants in TP53. The gene discussed is TP53; the disease is ovarian carcinoma.