Obesity is associated with high serum concentrations of leptin, which is linked to NF-κB activation, a mediating factor in the production of ROS and inflammatory cytokines.80 Nordfjall et al. confirmed the negative association between BMI and telomere length but in their study, this finding applied only to female participants.81 This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.