Therefore, we chose fixed-effects model to analyze the pooled OR, and found no significant association between the TNF-238G/A polymorphism and TB susceptibility (GA+AA versus GG model: OR=1.005, 95% CI=0.765–1.319, P=0.974; A versus G genotype model: OR=1.000, 95% CI=0.769–1.300, P=1.000) (Figure 2 and Figure 3). This evidence concerns the gene TNF and tuberculosis.