ACE and hepatocellular carcinoma: In the trial conducted by Yojishi and colleagues, a combination treatment with a vitamin K2 analogue (menatetrenone, 45 mg/day) and an angiotensin converting enzyme inhibitor (ACE-I) (perindopril, 4 mg/day) for 36–48 months after curative therapy for HCC markedly inhibited the cumulative recurrence of HCC, as well as suppressed of the serum levels of the vascular endothelial growth factor [4].