CCND1 and hepatocellular carcinoma: It has been suggested in the past that Vitamin K2 may be useful in preventing both the early and late type of recurrences [15] possibly by inhibiting the proliferation of HCC cells through cell cycle arrest at the G1 phase or via suppression of cyclin D1 expression through the IKK/IkappaB/nuclear factor-kappaB pathway [19,20].