PTEN and granulosa cell tumor: The phenotype of this model is in contrast with other reports that described the development of granulosa cell tumors in mice with conditional loss of Pten and conditional activation of β-catenin (Ctnnb1Δex3) induced either in the Amhr2-Cre line or through granulosa specific expression of Cre in the Cyp19Cre (Tg(CYP19A1-cre)1jri) line[57].