Interestingly, activation of the Akt and Wnt signaling pathways was also reported using Amhr2-Cre to inactivate Pten and activate the expression of a dominant stable β-catenin[53,56], however depending on the reporting laboratory, the mice either developed EC[56] in agreement with Wu et al. or granulosa cell tumors[53]. The gene discussed is AMHR2; the disease is granulosa cell tumor.