Wu et al. reported a statistical association of Pten mutations with Wnt pathway defects in ovarian endometrioid adenocarcinomas in clinical samples and used Ad-CMV-Cre to activate the Wnt pathway by deletion of Apc and the Akt pathway by deletion of Pten to give rise to ovarian endometrioid adenocarcinomas in 100% of mice. The gene discussed is PTEN; the disease is ovarian endometrioid adenocarcinoma.