NOS3 and Hyperglycemia: As it is well known, diabetes is characterized by hyperglycemia and hyperlipidemia, two biochemical features associated with inhibition of endothelial nitric oxide synthase (eNOS), leading to diminished NO production, increased formation of reactive oxygen species (ROS), impaired endothelium-dependent relaxation, increased formation of free radicals and lower efficacy of antioxidant systems, which lead to an imbalance between free-radical formation and the protection against them [32,38-40].