MAT2B expression has been shown to increase during liver cirrhosis and HCC development [1], [13], but its expression not always follows that of MAT2A. Early stages of Wilson disease in the Long Evans Cinnamon rat model showed the MAT1A to MAT2A hepatic switch, but a strong reduction in MAT2B expression [14]. This evidence concerns the gene MAT1A and hepatocellular carcinoma.