In cystic fibrosis, which is the most common fatal inherited disease in the western world [29], large quantities of F-actin and DNA released from lysed inflammatory cells are found in the surface airway liquid, together with polycationic antimicrobial polypeptides, such as LL-37, lysozyme, ß-defensin and lactoferrin [38]. The gene discussed is CAMP; the disease is cystic fibrosis.