This is a relevant observation to the function of CCHCR1 even though the CCHCR1*Iso3WWCC haplotype associates with decreased STAT3 activation, while epidermal keratinocytes within psoriatic skin are characterized by activated STAT3, and in transgenic mice the expression of constitutively active Stat3 leads to a psoriasis like skin phenotype [20], [55]. This evidence concerns the gene CCHCR1 and psoriasis.