CCHCR1 and psoriasis: Here we show that in HEK293 cells, the overexpression of CCHCR1 isoform 1 with the non-risk allele upregulates the expression of keratin 17 (KRT17), a hallmark and plausible auto-antigen for psoriasis [32], [40], [47], [48].Correspondingly, the silencing of CCHCR1 in HEK293 cells, which are homotsygous for the Iso1 allele and are therefore able to express also the isoform 1, reduces the KRT17 expression.