Here we show that in HEK293 cells, the overexpression of CCHCR1 isoform 1 with the non-risk allele upregulates the expression of keratin 17 (KRT17), a hallmark and plausible auto-antigen for psoriasis [32], [40], [47], [48].Correspondingly, the silencing of CCHCR1 in HEK293 cells, which are homotsygous for the Iso1 allele and are therefore able to express also the isoform 1, reduces the KRT17 expression. This evidence concerns the gene KRT17 and psoriasis.