IL-10-producing regulatory B (B10) cells have been identified to play a protective role in murine models of autoimmune diseases, including collagen-induced arthritis (CIA) [12],experimental autoimmune encephalomyelitis (EAE) [13], diabetes [14], contact hypersensitivity (CHS) [15], allergic airway inflammation [16], and intestinal mucosal inflammation [17]. Here, IL10 is linked to experimental autoimmune encephalomyelitis.