Heterogeneity in the patterning of HER2 protein expression among the different sites in individual cases was present with multiple patterns: detectable in all (6/50); detectable in primary but undetectable in metastatic tumor (8/50); detectable in metastatic but undetectable in primary tumor (5/50); detectable in at least one primary and one metastatic sites (7/50). Here, ERBB2 is linked to neoplasm.