The key finding of this study was that the diastolic dysfunction of aging men undergoing coronary artery bypass graft surgery was not associated with myocardial fibrosis or alteration in cardiomyocyte width, capillary length density, diffusion radius, arteriolar dimensions or myocardial expression of CML and RAGE, but was associated with plasma levels of CML and LMWFs, and these associations were dependent, in part, on age. Here, AGER is linked to Myocardial fibrosis.