NR1H4 and inflammatory bowel disease: However, we previously reported that, under unstimulated conditions, there is lower expression of ileal FXR target genes in patients with CC [13] This could be a secondary event due to a disturbed enterohepatic circulation of bile salts: absorption of bile acids in the ileum into the enterohepatic circulation may be impaired in inflammatory bowel disease, either through active ileal inflammation or through faster passage of intestinal contents through the intestinal tract [20], [21].