Diazoxide, a classical KATP channel activator, prevented rotenone-induced rat microglial activation (Zhou et al., 2008), inhibited NO release, tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6) production, and inducible nitric oxide synthase (iNOS) expression in a mouse model for multiple sclerosis in an induced experimental autoimmune encephalomyelitis (Virgili et al., 2011). The gene discussed is NOS2; the disease is experimental autoimmune encephalomyelitis.