The aim here was to study the relative distribution of LPL and its endothelial transport protein GPIHBP1 in mouse pancreas, and to study effects on LPL and GPIHBP1 expression in pancreas by changes in nutritional state (fed compared to fasted), diet composition (normal chow compared to high-fat diet) and by obesity due to leptin deficiency. The gene discussed is LPL; the disease is obesity due to melanocortin 4 receptor deficiency.