GCKR and diabetes mellitus: In the MONICA 1 study four genetic variants were significantly associated with incident CVD independently of baseline diabetes status; minor risk allele of SLC2A2 rs11920090 (HR 1.147, 95% CI 1.027–1.283 , P = 0.0154), major risk allele of C2CD4A rs7172432 (1.112, 1.027–1.205 , P = 0.0089), major risk allele of GCKR rs780094 (1.094, 1.007–1.188 , P = 0.0335) and major risk allele of C2CD4B rs11071657 (1.092, 1.007–1.183 , P = 0.0323) (table 2.