PTPN2 and central nervous system cancer: Recent reports have shown that a reduction in expression of Protein Tyrosine Phosphatase-1B (PTP1B) and T-Cell Protein Tyrosine phosphatase (TC-PTP) reduced ERK phosphorylation in MCF-7 cells [27], and PTPRM suppressed glioma cell migration by dephosphorylation of PLCγ1 [20].