Increased IL6 expression in either serum, saliva, or tumor tissues has been noted in patients with colorectal cancer, breast cancer, lymphoma, hepatocellular carcinoma, pancreatic carcinoma, renal cell carcinoma, bladder cancer, and multiple myeloma and it has been implicated in tumor development [8]–[18]. Here, IL6 is linked to hereditary clear cell renal cell carcinoma.