Unlike constitutively expressed heat shock cognate 70 (HSC70), inducible HSP70 is present at relative low level in untransformed cells, but is frequently observed at high level in tumor cells, in which HSP70 serves as a protective factor conferring resistance to stress-induced apoptosis [34] and suppression of default senescence pathway [35], and is associated with metastasis development and drug resistance [36]. Here, HSPA8 is linked to neoplasm.