In earlier studies, we showed that IL-4 induced transcriptional regulation of eotaxin-3 mRNA expression is mediated by STAT6 signaling in esophageal squamous cells from EoE patients and, in a number of other epithelial cell types, PPIs have been found to inhibit STAT6 phosphorylation [14], [16]. This evidence concerns the gene CCL26 and eosinophilic esophagitis.