For example, loss of DSG1 expression has been observed during human skin carcinogenesis and is associated with worse prognosis in head and neck squamous cell carcinomas (SCCs) [19], [20], and loss of DSG3 and DSC3 expression was noted during human oral squamous carcinoma development, suggesting roles for these desmogleins as tumor suppressors [21]. The gene discussed is DSG3; the disease is neoplasm.