In this review, the most studied candidate genes for LDD were vitamin-D receptor (VDR), aggrecan (ACAN), interleukin-1 alpha (IL1A), interleukin-1 beta (IL1B), collagen IX alpha 2 (COL9A2) and collagen IX alpha 3 (COL9A3) (Table S1). The gene discussed is IL1A; the disease is Lhermitte-Duclos disease.