Interestingly, a bi-genic mouse line that has repressed FGFR2 combined with high FGFR1 activity (resembling our shR2 cells) shows enhanced tumor development in the prostate when compared to either repression of FGFR2 or overexpression of FGFR1 alone [36]. This evidence concerns the gene FGFR2 and neoplasm.