CD4 and lymphedema: [22] Our group has previously shown that fibrosis is a critical regulator of lymphatic function and lymphatic regeneration [14], [15], [23], [24] and fibrosis is a clinical histopathologic hallmark of lymphedema. [25] Therefore, in these experiments we sought to determine if CD4 or CD8 cell inflammation contributes to fibrosis and lymphatic dysfunction in the mouse tail model of lymphedema.