The AMD smokers and AMD never smokers showed significant TT frequency as compared to control smokers and control never smokers for CCL2 (OR = 5.80, p = 0.040, CI = 1.081–31.112 and OR = 3.380, p = 0.019, CI = 1.223–9.347, Table S2) and TT frequency was significantly higher in AMD smokers as compared to control smokers for CCR2 (OR = 15.6, p = 0.016, CI = 1.662–146.4, Table S2). The gene discussed is CCR2; the disease is age-related macular degeneration.