Concerning the relationship of circulating IGFBP-3 concentration and lung cancer risk, the pooled OR 0.960 (95%CI:[0.591,1.559], P = 0.868) (Fig. 2B) as well as to SMD −0.097 (95%CI:[ −0.264,0.071], P = 0.258) (Fig. 2D) were calculated similar to that of IGF-1. Here, IGF1 is linked to lung cancer.