SERPINB3 and cancer: In addition, SERPINB3 attenuates apoptosis mediated by anti-cancer drugs for NK cells and by inhibiting cytochrome c release from the mitochondria [20], [21], [22] Moreover, glandular morphogenesis associated with SERPINB3 may contribute to epithelial-mesenchymal transition, which may deregulate the adhesion process to allow metastasis and increase the invasiveness potential of tumor cells in women [23].