Although IGFBP3 also showed a greater underexpression in PCa oETS+ when compared to PCa ERG+, there was a non-significant increase in IGFBP3 expression after DAC treatment of the ETV1-positive LNCaP cell line, precluding a consistent relationship between higher IGFBP3 methylation levels and ETV1 rearrangements. The gene discussed is ETV1; the disease is posterior cortical atrophy.