Although we were not able to detect differences among PCa subgroups, overall, higher promoter methylation frequencies of CAV1, IGFBP3 and ECRG4 were found in PCa compared to NPT (p = 0.010 for CAV1, p<0.001 for IGFBP3 and p = 0.008 for ECRG4). This evidence concerns the gene IGFBP3 and posterior cortical atrophy.