In order to investigate whether these ETS fusion genes have some common downstream targets, we crossed a publicly available list of all putative EWSR1-FLI1 direct target genes in ESFT (obtained by chromatin immunoprecipitation coupled with DNA microarrays) [20] with our microarray expression data on PCa with and without ERG rearrangements [25] and validated the findings in an independent series of PCa and ESFT. The gene discussed is EWSR1; the disease is posterior cortical atrophy.