Although there is no direct evidence of the role of the VNN1 protein in HDL-C levels regulation, it is known that VNN1 codes for pantetheinase and produces cysteamine, a potent antioxidant that prevents lipid peroxidation [13], [14] and has been associated with other metabolic traits such as obesity in animal models [15]. Here, VNN1 is linked to obesity due to melanocortin 4 receptor deficiency.