Finally, It is noteworthy that a large scale genetic linkage study including more than 800 multiplex families and applying a pathway and network ranking method, has identified the loci of OGG1 and STMN1 in a cluster of interacting genes associated with schizophrenia, those of TERT and CDKN2A in a cluster associated with autism, and that of CDKN2A in a cluster associated with bipolar disorder [53]. The gene discussed is CDKN2A; the disease is bipolar disorder.