Similar to CCS colorectal cancer cells, after enrichment of TICs with the increased expression of markers such as Oct4, Nanog and SOX2 (Figure 6A), there was an increase in PP2A phosphorylation, and an increase in p38MAPK, MAPKAPK2 and Hsp27 activation in HCW, a primary liver metastasis of colorectal cancer [15], A549, a lung adenocarcinoma cell line, HTB-186, medulloblastoma cells and SAS, primary oral cancer cells (Figure 6B). The gene discussed is SOX2; the disease is lung adenocarcinoma.