The difference in the magnitude of CD8+ T-cell IFN-γ responses to autologous versus consensus peptides was more evident in primary infection (day 92) for the high viremic subject (11.98% versus 7.09%) and in the chronic phase (day 372) for the low viremic subject (0.54% versus 0.32%), with the high and low viremic subjects demonstrating divergent responses over time (Figure 2c). Here, CD8A is linked to infection.