Gag and Nef proteins contain the highest density of epitopes recognized by T-cell responses [4]–[6] and HIV-1 Nef, an early viral regulatory protein, is the dominant CD8 T-cell targeted protein during primary HIV infection, while responses to HIV-1 Gag dominate the CD8 T-cell response during the chronic phase [4]. This evidence concerns the gene CD8A and HIV infectious disease.