Interestingly, in the sample from the chronic phase of infection (day 448), the CD8+ T-cell IFN-γ response to this consensus peptide decreased and the magnitude of response to both autologous peptides 5173a and 5173b (LTFGWCFKLVPMEED and LTFGWCYKLVPMEED) remains stable or became strongly positive respectively. The gene discussed is CD8A; the disease is infection.