Also, 7 genes (CTGF, ESR1, MAPK3, PIK3R3, PLAU, PRNP, and RET) were reported to be highly relevant to growth (P<1E-04) and microtubule dynamics (P<4E-05) in tumor cell lines, and apoptosis in breast cancers (P<1E-04) [32], [33], [34], [35]. The gene discussed is ESR1; the disease is breast carcinoma.