These actions are similar to those of metformin, a compound known to partially inhibit respiratory complex I. We speculate that the increased glucose uptake and lactic acid production are a consequence of increased glycolysis that partially compensates for the decrease in mitochondrial ATP production in the setting of loss of function of ATM, suggesting that neoplasms involving loss of function of ATM will exhibit a “Warburg” metabolic phenotype. This evidence concerns the gene ATM and neoplasm.