The significant synergy with mTOR inhibitors including rapamycin and radiation reported by Shinohara et al [20] may point out the characteristic influences of the microenvironment of each tumor type as pointed out in other studies where the synergy was attributed only to rapamycin targeting the enhanced activity of signaling pathways controlled by mTOR in the host endothelial cells [41]. Here, MTOR is linked to neoplasm.