However, changes over baseline were significantly more marked in HI than in LI subgroup for triglycerides and total cholesterol, but not for fasting blood glucose, insulin, HOMA-IR index, systolic and diastolic BP, waist, BMI, HDL and LDL cholesterol, high sensitivity-C-reactive protein, and total and fatal CHD risk scores (Table 1). The gene discussed is CRP; the disease is coronary artery disorder.