When compared with the CON group, changes over baseline in both the LI and HI subgroups were significantly more marked for HbA1c, HOMA-IR, serum insulin, systolic and diastolic BP, total, HDL- and LDL-cholesterol, waist, BMI, high sensitivity-C-reactive protein, and total and fatal CHD 10-year risk scores (not shown), as previously reported for comparison of the whole EXE group with CON participants (9). This evidence concerns the gene INS and coronary artery disorder.