In addition, stratified analysis indicated TT-genotype carriers of rs3218038 (G>T) in CCNE1 had unfavorable event-free survival compared with those carrying common G allele among patients with aggressive tumours (in tumour size>2 cm group: HR = 2.06, 95% CI = 1.06–3.99, P = 0.033; in positive lymph node metastasis group: HR = 2.41, 95% CI = 1.15–5.03, P = 0.019; in clinical stage II–IV group: HR = 2.03, 95% CI = 1.09–3.79, P = 0.027) (Table 5; Figure 3A–D). This evidence concerns the gene CCNE1 and neoplasm.