CCNE1 and breast cancer: However, in CCNE1, the 5-SNP haplotype pairs (diplotype) TTTAC/TTTAC (rs8102137, rs3218035, rs3218038, rs3218042 and rs1406), which carried two minor alleles of 3 at-risk SNPs, rs3218035 (C>T), rs3218038 (G>T) and rs3218042 (T>A), could increase about 2.3-fold of BC risk compared with common diplotype TCGTC/TCGTA (OR = 2.35, 95% CI = 1.09–5.08, P = 0.029) (Table S3).