In stratified survival analysis, TT genotype of rs3218038 in CCNE1 was associated with a worse event-free survival among patients with aggressive tumours (in tumour size>2 cm group: HR = 2.06, 95% CI = 1.06–3.99; in positive lymph node metastasis group: HR = 2.41, 95% CI = 1.15–5.03; in clinical stage II–IV group: HR = 2.03, 95% CI = 1.09–3.79). The gene discussed is CCNE1; the disease is neoplasm.