Notably, we found that the genes involved in the Wnt pathway were enriched (P = 0.026; Table 6, Figure S1), and four genes (FZD5, LRP6, PPP2R1B, and TBL1XR1) in this pathway switched to proximal APA sites in nasal polyp tissue. The gene discussed is TBL1XR1; the disease is Nasal polyposis.