To elucidate the mechanism of action of V1801, its effects on the expression of antiapoptotic proteins (Bcl-xl and Mcl-1) and proapoptotic proteins (Noxa, Puma and Bim) of Bcl-2 family were tested in NSCLC cells with RT-PCR analysis. Here, PMAIP1 is linked to non-small cell lung carcinoma.